Publications

Link to PubMed

  1. Cao K FM, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis EA, Yang J. Aminonaphthlanene 2-Cyanoacrylate (ANCA) Probes Fluorescently Discriminate between Amyloid-β and Prion Plaques in Brain. Journal of the American Chemical Society, 2012.

  2. Mitchell, GB, Sigurdson, CJ, O’Rourke, KI, Algire, J, Harrington, NP, Walther, I, Spraker, TR, Balachandran, A. Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus). PLoS One. 2012.

  3. Perrott, MR, Sigurdson, CJ, Mason, GL, Hoover, EA. Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets, Journal of General Virology. 93 (2012) 212-221.

  4. Sajnani, G, Silva, CJ, Ramos, A, Pastrana, MA, Onisko, BC, Erickson, ML, Antaki, EM, Dynin, I, Vazquez-Fernandez, E, Sigurdson, CJ, Carter, JM, Requena, JR. PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP, PLoS Pathogens. 8 (2012) e1002547.

  5. Bett, C, Joshi-Barr, S, Lucero, M, Trejo, M, Liberski, P, Kelly, JW, Masliah, E, Sigurdson, CJ. Biochemical properties of highly neuroinvasive prion strains. PLoS Pathogens. 8(2):e1002522. Epub Feb 2, 2012.

  6. Sigurdson, CJ, Joshi-Barr, S, Bett, C, Winson, O, Manco, G, Schwarz, P, Rülicke, T, Nilsson, P, Margalith, I, Raeber, A, Peretz, D, Hornemann, S, Wüthrich, K, and Aguzzi, A. Spongiform encephalopathy in transgenic mice expressing a point mutation in the beta2-alpha2 loop of the prion protein. Journal of Neuroscience. 31(39):13840-13847. 2011.

  7. Sigurdson CJ, Bartz, JC, Nilsson, KPR. Tracking protein aggregate interactions. Prion. Apr 1; 5(2): 52-5, 2011.

  8. Chang, WM, Dakanali, M, Capule, CC, Sigurdson, CJ, Yang, J, and Theodorakis, EA. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chemical Neuroscience. 2(5):249-255. 2011.

  9. Ligios, C, Cancedda, MG, Carta, A, Santucciu, C, Maestrale, C, Demontis, F, Saba, M, Patta, C, Demartini, JC, Aguzzi, A and Sigurdson, CJ. Sheep with scrapie and mastitis transmit infectious prions through the milk. Journal of Virology. 85:1136-9, 2011.
    • Selected by the journal editors for Spotlight: Articles of Significant Interest from this issue

  10. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nature Reviews Neurology. Dec;6(12):702-6, 2010.

  11. Wegrzyn, JL, Bark, SJ, Funkelstein, L, Mosier, C A, Yap, A, Kazemi-Esfarjani, P, La Spada, A, Sigurdson, C, O’Connor, DT, and Hook, VY. Proteomics of Dense Core Secretory Vesicles Reveal Distinct Protein Categories for Secretion of Neuroeffectors for Cell-Cell Communication, Journal of Proteome Research. 9(10):5002-24, 2010.

  12. Sandberg M, Al-Doujaily H, Sigurdson C, Glatzel M, O’Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, and Collinge J. Chronic wasting disease prions are not transmissible to transgenic mice over-expressing human prion protein. Journal of General Virology. 91, 2651-2657, 2010.

  13. Nilsson, KPR, Joshi_Barr, S, Winson, O, Sigurdson, CJ. Prion strain interactions are highly selective. Journal of Neuroscience. 30, 12094-12102, 2010.

  14. Sigurdson, CJ, Nilsson, KPR, Hornemann, S, Manco, G, Fernández-Borges, N., Schwarz, P, Castilla, J, Wüthrich, K, and Aguzzi, A. Prion protein loop structure influences cross-species prion disease transmission in mice. The Journal of Clinical Investigation. 120(7):2590-9, 2010.

  15. Aslund, A., Sigurdson, CJ, Klingstedt, T., Grathwohl, S., Bolmont, T., Dickstein, D. L., Glimsdal, E., Prokop, S., Lindgren, M., Konradsson, P., Holtzman, D. M., Hof, P. R., Heppner, F. L., Gandy, S., Jucker, M., Aguzzi, A., Hammarstrom, P. and Nilsson, K. P. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chemical Biology. 2009

  16. Sigurdson, CJ, Nilsson, KPR, Heikenwalder, M, Hornemann, S, Manco, G, Schwarz, P, Ott, D, Rulicke, T, Liberski, P, Julius, C, Stitz, L, Wüthrich, K, and Aguzzi, A. De novo generation of a transmissible spongiform encephalopathy by murine transgenesis. Proceedings of the National Academy of Science. U S A, 106(1): 304-309, 2009.
    • Commentary on this article: Soto, C. Constraining the loop, releasing prion infectivity. Proceedings of the National Academy of Science, U S A, 106(1): 10-1, 2009.

  17. Sigurdson, CJ, Heikenwalder, M, Manco, G, Barthel, M, Schwarz, P, Stecher, B, Hardt, W, Seifert, B, MacPherson, AJS, Corthesy, I, and Aguzzi, A. Bacterial Colitis Increases Susceptibility to Oral Prion Disease. Journal of Infectious Diseases. 199(2): 243-252, 2009.

  18. Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS ONE. 3(12): e3872, 2008.

  19. Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 29(6): 998-1008, 2008.

  20. Sigurdson, CJ, Mathiason, CK, Perrott, MR, Eliason, GA, Spraker, TR, Glatzel, M, Bartz, JC, Miller, MW, Hoover, EA. Experimental chronic wasting disease (CWD) in the ferret. Journal of Comparative Pathology. 138(4): 189-196, 2008.

  21. Sigurdson, CJ. Chronic wasting disease. Veterinary Research special issue on Prion Diseases of Animals. 39(4):41-53, 2008.

  22. Aguzzi, A., Sigurdson, C, Heikenwälder, M. Molecular mechanisms of prion pathogenesis. Annual Review of Pathology. 3:11-40, 2008.

  23. Sigurdson CJ*, Nilsson KP*, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. Prion strain discrimination using luminescent conjugated polymers. Nature Methods. 4(12):1023-30, 2007. (*equal contribution.)
    • News and Views on this article: Jackson, W. S. and S. Lindquist. Illuminating aggregate heterogeneity in neurodegenerative disease. Nature Methods. 4(12): 1000-1, 2007.

  24. Sigurdson, CJ and Aguzzi, A. Chronic wasting disease-review. Biochimica and Biophysica Acta special issue on Prion-Related Disorders. 1772(6):610-8, 2007.

  25. Sigurdson, CJ, Manco, G, Schwarz, P, Liberski, P, Hoover, EA, Hornemann, S, Polymenidou, M, Miller, MW, Glatzel, M, Aguzzi, A. Strain fidelity of chronic wasting disease upon murine adaptation. Journal of Virology. 80(24):12303-11, 2006.

  26. Mathiason, CK, Powers, JG, Dahmes, SJ, Osborn, DA, Miller, KV, Warren, RJ, Mason, GL, Hays, SA, Hayes-Klug, J, Seelig, DM, Wild, MA, Wolfe, LL, Spraker, TR, Miller, MW, Sigurdson, CJ, Telling, GC, and Hoover, EA. Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease. Science. 314(5796):133-6, 2006.

  27. Angers, RC, Browning, SR, Seward, TS, Sigurdson, CJ, Miller, MW, Hoover, EA, Telling, GC. Prions in skeletal muscles of deer with chronic wasting disease. Science. 311(5764):1117, 2006.

  28. Ligios C*, Sigurdson, CJ*, Santuddiu, C*, Carcassola, G, Manco, G, Basagni, M, Maestrale, C. Cancedda MG, Madau, L, Aguzzi, A. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nature Medicine. 11(11):1137-8, 2005. (*equal contribution)

  29. Sigurdson, CJ, Polymenidou, M and Aguzzi, A. Reconstructing prions: fibril assembly from simple yeast to complex mammals: A discussion of the latest international transmissible spongiform encephalopathy (TSE) meeting. Neurodegenerative Disease. 2:l-5, 2005.

  30. Sigurdson, CJ, Glatzel, M, Aguzzi, A. Comment on “Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy”, Veterinary Pathology. 42(1):107, 2005.

  31. Aguzzi, A, Sigurdson, CJ. Antiprion immunotherapy: to suppress or to stimulate? Nature Reviews Immunology. 4(9):725-36, 2004.

  32. Heikenwalder, M, Polymenidou M, Junt, T, Sigurdson, CJ, Wagner, H, Aguzzi, A. Germinal center destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nature Medicine. 10(2):187-194, 2004.

  33. Sigurdson, CJ, Barillas-Mury, C, Miller, MW, Oesch, B, van Keulen, LJM, Langeveld, JPM, and Hoover, EA. PrPCWD lymphoid cell targets in early and advanced chronic wasting disease. Journal of General Virology. 83:2617-28, 2002.

  34. Wild, MA, Spraker, TR, Sigurdson, CJ, O’Rourke, KI, and Miller, MW. Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy. Journal of General Virology. 83:2629-34, 2002.

  35. Sigurdson, CJ, Basaraba, RJ, Mazzaferro, E, Gould DH. Globoid Cell Leukodystrophy in a Domestic Longhaired Cat. Veterinary Pathology. 39(4):494-6, 2002.

  36. Spraker, TR, Zink, RR, Cummings, BA, Sigurdson, CJ, Miller, MW, O’Rourke, KI. Patterns of distribution of PrPres and spongiform encephalopathy in brain and PrPres in palatine tonsil of non-clinical mule deer (Odocoileus hemionus) with chronic wasting disease. Veterinary Pathology. 39(5):546-56, 2002.

  37. Sigurdson, CJ, Spraker, TR, Miller, MW, Oesch, B, and Hoover, EA. PrPCWD in the peripheral nerves and endocrine glands of mule deer with chronic wasting disease. Journal of General Virology. 82:2327-34, 2001.

  38. Sigurdson, CJ, Williams, ES, Miller, MW, Spraker, TR, O’Rourke, KI and Hoover, EA. Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns. Journal of General Virology. 80(10):2757-64, 1999.

  39. Loneragan, GH, Gould, DG, Callan, RJ, Sigurdson, CJ, Hamar, DW. Association of excess total sulfur intake and an increase in H2S concentrations in polioencephalomalacia. Journal of the American Medical Association. 213:1599-1604, 1998.